CINSW Model of Translational Research
 Westfall et al., 92007). Practice-based research - "blue
highways" on NIH roadmap. JAMA, 297(4): 403-406. NSW Health and
Medical Strategic Review - the Wills Review, p4 (2012).
Figure 1(above) is the agreed model of translational research
adopted by the Cancer Institute NSW for all its translational
grants. This model focuses on the translation of basic research
into clinical research as well as being applicable to the
translation of population health and health services research
informing programs and service delivery. T3 research is
particularly significant for the Cancer Institute NSW because it
focuses directly to improving the efficiency of services and the
way programs are provided.
Figure 1 outlines /classifies the stages of translational
- T1 ‐ developing treatments and interventions.
- T2 ‐ testing the efficacy and effectiveness of these treatments
- T3 ‐ dissemination and implementation research for system‐wide
Detailed Translational Pipeline
T1 ‐Translation to Humans
- Developing treatments and interventions
- The translation of basic research into research with humans.
Basic research could cover a range of disciplines including:
laboratory research, epidemiology, psychometrics, social
- The interface between basic research and the clinical setting,
striving to find how new knowledge of disease mechanisms can be
developed into clinically relevant understandings, and diagnostic
and treatment regimes to be trialled in humans.
- Types of studies/activities - Observational studies, Case
studies; Phase 1 and II clinical trials
T2 ‐Translation to Patients
- Testing the efficacy and effectiveness of these treatments and
- The translation of new clinical science and knowledge into
routine clinical practice and health decision making (see Grimshaw
- The application of information and insights derived from basic,
clinical and population health research to the provision of health
services (see Wills NSW Health & Medical Review of Strategic
- Translation of new clinically proven knowledge of disease
processes, diagnostic or treatment techniques into routine clinical
practice and health decision making.
- Types of studies/activities ‐ Phase III clinical trials;
observational studies; evidence synthesis and guidelines
T3 ‐Translation to Practice
- Dissemination and implementation research for system‐wide
- Moving evidence‐based guidelines into health practice, through
delivery, dissemination, and diffusion research.
- Practice based research, where the evidence from clinical
trials on carefully selected patients is translated into guidelines
for complex patients seen routinely in practice.
- Types of studies/activities ‐ Dissemination research;
implementation research; diffusion research, Phase IV clinical