Paul is a member of the Scientific Advisory Committee.
Background:
Paul completed his PhD with Professor Margaret Frame at the
Beatson Institute for Cancer Research, UK in 2002 where he assessed
the interplay between Src family kinases and the actin cytoskeleton
during cancer cell invasion, focusing on the Rho family GTPases. He
then moved to the Garvan Institute in 2003 to work with Professor
Roger Daly investigating the role of the actin-binding protein
cortactin in growth factor receptor trafficking in breast cancer
and head and neck cancers.
Paul was awarded tan AstraZeneca Postdoctoral Research
Fellowship allowing him to return to the Beatson Institute in 2007,
to work with Professor Kurt Anderson in collaboration with
AstraZeneca Advanced Technology Laboratories. This ongoing work has
focused upon the development of novel multi-disciplinary live
imaging techniques to investigate molecular dynamics of cancer
cells in vivo.
Returning to Australia to establish a research group in November
2012 within the Cancer Program, Paul aims to understand disease in
the context of the surrounding environment using cutting edge in
vitro and in vivo imaging technology. Pinpointing the molecular
drivers of cancer progression and the environmental cues that cause
resistance to current systemic therapy are the focus of his
research.
Research Interests:
Paul has a special interest in intravital imaging, invasion and
metastasis, tumour associated microenvironment, pre-clinical
imaging, biosensors and drug discovery, PhoGTPases, E-cadherin
cell-cell junctions, Src family kinases, signal transduction and 3D
modelling of disease.