Associate Professor Thomas Cox

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Associate Professor Thomas Cox currently leads the Matrix and Metastasis Group at the Garvan Institute of Medical Research in Sydney. His team focuses on how the extracellular matrix (ECM) regulates resident cell behaviour and specifically how it contributes to cancer progression, metastasis and response to therapy. Recent work has focussed on how discrete subtypes of cancer associated fibroblasts (CAFs) within tumours underpin ECM remodelling programs that generate pro-invasive and pro-metastatic environments (Nature Communications 2019); the development of new techniques to image the ECM in health and disease (Nature Medicine 2017); and the systemic role of ECM remodelling in premetastatic niche formation (Nature 2015). The aim of Thomas' group is to establish targeting of ECM dynamics as a viable therapeutic approach in the treatment of solid tumours.