Professor Jeff Holst

Background:  

Professor Jeff Holst leads the Translational Cancer Metabolism Laboratory in the Adult Cancer Program at the University of NSW. Jeff completed his PhD at St Vincent's Hospital/University of NSW and undertook postdoctoral studies at St Jude Children's Research Hospital, Memphis TN in immunology. He returned to Australia in 2006, starting a lab at the Centenary Institute focussing on the role of amino acid transport in cancer, including funding through Sydney Catalyst. In 2018, he was recruited to the University of NSW where he continues his work understanding the role of amino acid uptake and metabolism in melanoma, glioblastoma, breast and prostate cancer, with a particular focus on glutamine metabolism. His work examines the basic biology regulating amino acid transporter expression and function, the downstream metabolic pathways, as well as developing new therapeutic strategies to target these pathways.