Associate Professor Thomas Cox

Background:  

A/Prof. Thomas Cox is an NHMRC Career Development Fellow who currently leads the Matrix and Metastasis Group at the Garvan Institute of Medical Research in Sydney. His team focuses on how the extracellular matrix (ECM) regulates resident cell behaviour and specifically how it contributes to cancer progression, metastasis and response to therapy. Recent work has focussed on how discrete subtypes of cancer associated fibroblasts (CAFs) within tumours underpin ECM remodelling programs that generate pro-metastatic and chemoprotective environments (Nature Communications2019); the development of new techniques to image the ECM in health and disease (Nature Medicine2017); and the systemic role of ECM remodelling in pre-metastatic niche formation (Nature2015). The aim of Thomas' group is to establish targeting of ECM dynamics as a viable therapeutic approach in the treatment of solid tumours.