Top image

In vivo photolabeling of tumor-infiltrating cells

DATE
30 May 2016
PUBLICATION / RESOURCE TYPE
T1
TOPIC
  • Immunotherapy
  • Tumour immunity

Summary

Understanding the consequences of immune infiltration of solid tumors is vital to continued development of successful immune therapies. However, little is known about the fate of tumor-experienced leukocytes. Here we used in vivo photoconversion to label tumor-infiltrating cells and demonstrated specific egress and dissemination of effector T-cell subsets from tumors. The identity and functions of tumor-egressing cells, and those retained inside tumors, are of great importance to our understanding of tumor immunity because of the crucial role tumor-infiltrating cells play in primary tumors and their potential to provide antitumor immunity at secondary tumor sites and in secondary lymphoid organs. The results of this study will guide strategies that harness T-cell immunity for anticancer therapies.

Source: http://www.pnas.org/content/114/22/5677.full 

Full text available here, with permission of fellow Sydney Catalyst member Tatyana Chtanova, Garvan

 

Back to list