Sydney Catalyst - Our Research

T2,T3 | Flagship 2 Pilot and Seed

Development and implementation barriers of a new patient-reported outcome measure for radiotherapy related inconvenience

With more than 14 million new cases of cancer being diagnosed globally each year, radiation therapy (RT) has the potential to improve the rates of cure of 3.5 million people by eradicating tum...

Radiation oncology

T2,T3 | Flagship 2 Pilot and Seed

Pilot evaluation of the implementation of systematic melanoma risk assessment and tailored skin surveillance and patient education in dermatology clinics

Currently, melanoma screening and surveillance strategies are undertaken opportunistically and mostly rely on a one-size fits all approach or are based around single risk factors such as age, ...

Skin cancer

T1,T2 | Flagship 2 Pilot and Seed

Dual targeting of stromal and immunological aberrations in pancreatic cancer by combining perlecan inhibition with immunotherapy

Pancreatic cancer is the 4th leading cause of cancer deaths and has a dismal 5-year survival of <9%, with no meaningful changes in the last four decades. One of the reasons the prognosis is ...

ImmunotherapyPancreatic cancer

T1,T2 | Flagship 2 Pilot and Seed

Improving survival in melanoma by matching optimal drug therapy for individual patients

Checkpoint inhibitor immunotherapy has revolutionized the management of advanced melanoma and significantly improved survival. However, half of these patients still die of melanoma. Ther...

ImmunotherapySkin cancer

WHAT IS EnRICH? The EnRICH program is a prospective clinical cohort of 1000 patients with lung cancer, which aims to better define, treat and care for patients in Sydney Catalyst member hosp...

T2,T3 | Flagship 2 Pilot and Seed

Very low-energy diet before surgery in obese patients undergoing partial liver excision: A pilot randomised control trial (Very Supple Trial)

Obesity in Australia is an increasingly concerning issue in healthcare. Obesity has been shown to make abdominal surgery more technically challenging and is associated with poorer outcomes. St...

Surgery

T2,T3 | Flagship 2 Pilot and Seed

Ensuring the symptoms of vulnerable populations are known: Identifying patient barriers and facilitators to completing PROMs in cancer care

In Australis there are over 300 separately identified languages spoken in homes, with over 20% of Australians speaking a language other than English. In some health care services, this equals a...

PsychosocialImplementation research

T2,T3 | Flagship 2 Pilot and Seed

Aerobic exercise training during chemotherapy infusion

Cancer and its treatment often cause physical and psychological side effects. Exercise is well known to benefit people with cancer, especially during treatment. It can reduce side effects such ...

Evidence into practiceKnowledge translationTreatmentExercise

T1,T2 | Flagship 2 Pilot and Seed

Unraveling the metabolic link between the host and breast cancer disease progression

Obese and diabetic patients have a far higher risk that lean, healthy people of getting breast cancer, and have worse outcomes when they do get cancer. These examples highlight the crucial and ...

Breast CancerMetastasis

T1,T2 | Flagship 2 Pilot and Seed

Intravital imaging to overcome pancreatic cancer resistance to immunotherapy

Survival rates in pancreatic cancer have been at a low standstill (5-year survival of ~9%) for the last decades. There is therefore an urgent need to assess new treatment strategies to effecti...

ImagingImmunotherapyPancreatic cancer