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Ben Kong: Towards a therapeutic vaccination for glioblastoma multiforme

RESEARCH TYPE
T1
PROGRAM
Flagship 3 Scholarships & Awards
TAGS
    Dendritic cell
    Immunotherapy
STATUS
In Progress

The ultimate objective of Ben's research is to create an effective dendritic cell based vaccine for glioblastoma multiforme by exploiting knowledge of DC biology to find the optimum combination of dendritic cell based vaccines with "immune checkpoint" inhibiting molecules for translation into the clinic. It is well known that anti-PD-1 drugs such as pembrolizumab and nivolumab work by unleashing T cells against tumour cells, but the lesser known function of the PD-1 ligands, PD-L1 and PD-L2 on dendritic cells has not been fully explored. It is possible to "load" a wide variety of unique tumour derived antigens onto dendritic cells to utilise their function as the most powerful antigen-presenting cell in the body.

Ben's research project encompasses several Sydney Catalyst institutions, linking the clinical expertise at Concord Repatriation General Hospital and Chris O'Brien LifeHouse with the basic science expertise at the ANZAC Research Institute. There is an obvious application for translation of DC vaccines into the clinic, but equally the networks formed through such research will continue enhance the mission of Sydney Catalyst to boost translational research opportunities in the future. 

Scholarship Awarded:

  • Name: Ben Kong
  • Member Group: University of Sydney
  • Year and Duration: 2017 for two years
  • Amount: Top Up $40,000

Select Publications/Presentations:

In progress

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