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David Croucher: Mapping and manipulating therapeutically induced JNK network architecture to tackle breast cancer chemoresistance

RESEARCH TYPE
T1
PROGRAM
Sydney Catalyst Supported
TAGS
    Breast Cancer
    Chemo resistance
STATUS
Complete

The current generation of cancer therapies mostly target components of signalling pathways, being either small molecule inhibitors or monoclonal antibodies to cell surface receptors. It is fast becoming apparent that the inherent flexibility of signalling pathways mean that targeting a single pathway can lead the emergence of a resistant sub-population of tumour cells. In response to this clinical challenge Garvan have been developing the methods required to characterise relevant breast cancer related signalling pathways to utilise these methods to address the significant issue of chemoresistance in breast cancer."

CIA: Dr David Croucher

Award: 2013 CINSW FRL

 

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